The Delaware senator was responding to news that Clinton suggested in two recent interviews that Pakistani President Pervez Musharraf is up for reelection this month.
Musharraf was actually reelected in October, and the upcoming Pakistani elections are parliamentary, not presidential.
"We have a number of candidates who are well-intentioned but don't understand Pakistan," Biden said at a campaign event Tuesday. "One of the leading candidates - God love her."
"There are good people running," continued the chairman of the Senate Foreign Relations Committee, who has made his foreign policy credentials a centerpiece of his long shot presidential bid. "But to say Musharraf is up for election! Musharraf was elected - fairly or unfairly - president six months ago. It's about a parliamentary election!"
Clinton's comments came in an interview with ABC Sunday, in which she said, "[Musharraf] could be the only person on the ballot. I don't think that's a real election."
The New York senator also made similar comments during an interview with CNN's Wolf Blitzer last week, saying then, ""If President Musharraf wishes to stand for election, then he should abide by the same rules that every other candidate will have to follow."
Both gaffes were first noted by conservative Thomas Houlahan, writing for the Middle East Times.
The Clinton campaign has not yet returned a request for comment on Biden's comments, but said yesterday the New York Democrat was referring to Musharraf's party, not himself in particular.
Republican Mike Huckabee took heat last week for also getting key facts about Pakistan wrong in the aftermath of Benazir Bhutto's death. He first suggested the country remained under martial law (it was lifted a few weeks ago) and later said that Pakistan shares its eastern border with Afghanistan (it shares its western border.)
– CNN Ticker Producer Alexander Mooney