(CNN) - Arizona Sen. John McCain - whose support of illegal immigration reform nearly derailed his presidential bid two years ago - will face a Senate primary challenge next year from Minuteman founder Chris Simcox.
Simcox, who has resigned from the volunteer organization with the mission of preventing illegal crossings of the U.S. border, will formally announce his Senate bid on Wednesday.
"John McCain has failed miserably in his duty to secure this nation's borders and protect the people of Arizona from the escalating violence and lawlessness," Simcox said in a statement. "He has fought real efforts over the years at every turn, opting to hold our nation's border security hostage to his amnesty schemes."
"Coupled with his votes for reckless bailout spending and big government solutions to our nation's problems, John McCain is out of touch with everyday Arizonans. Enough is enough," he added.
McCain's presidential hopes were nearly dashed after teaming up with Massachusetts Sen. Ted Kennedy on the Comprehensive Immigration Reform Act of 2007, a measure that provided a path to citizenship for illegal immigrants currently residing in the United States.
McCain later backtracked from calling for a path to citizenship and, at a CNN debate in January 2008, said he would not have voted for the legislation if it reached the Senate floor.
"No, I would not, because we know what the situation is today," he said of voting for the bill he sponsored. "The people want the borders secured first."
A week before Monday's Homeland Security field hearing on border security in Phoenix, Arizona, McCain criticized the Obama administration's plan for immigration reform.
He said he could not support the plan, which he said "does not adequately address either securing the border or a legal temporary worker program."
"We need to act on the pressing issue of border security now, and then seek comprehensive immigration legislation that includes a temporary worker program," McCain said in a statement April 14. "Any legislation that does not address these two key components is not real reform."
McCain did not face a primary challenger in 2004 and won reelection with over 75 percent of the vote.