(CNN) - Senator Tom Coburn says he's running for re-election next year.
The conservative Republican from Oklahoma, who's become a crusader against government earmark spending, made his announcement at a news conference in Tulsa.
"I have made a decision that I will seek a second and final term in the U.S. Senate," announced Coburn.
He was adamant that this will be his last re-election effort, saying "when I say final term, it mean final term. There will be no other term after this."
Coburn, who's also a doctor, was first elected to the Senate in 2004, defeating Democrat Brad Carson by 12 points.
Oklahoma is heavily dominated by Republicans. John McCain won the state by 30 points in last November's presidential election. Political analysts say Coburn is heavily favored to win re-election.
"The Sooner state has turned into one of the most reliable bastions of conservatism, and this is one state where Republicans are in ascendant," says Stuart Rothenberg, editor and publisher of the non-partisan Rothenberg Political Report.
Coburn was elected to the House of Representatives as part of then House Speaker Newt Gingrich's "Republican Revolution." He served three terms in the House from 1995 to 2001.