If he's successful, Senate Democrats can breathe a sigh of a relief momentarily - but it's too early for them to celebrate. The road to final passage of health care legislation is still long and bumpy.
Reid needs 60 votes for the procedural vote this weekend, another 60 votes to close debate - which could last for weeks - but only 51 for final passage. Reid has said he hopes to vote on the final bill before the end of the year. President Obama's original deadline for Congress was last August.
The House passed its version of health care reform two weeks ago, with 220 representatives voting in favor and 215 against. Thirty-nine Democrats opposed the plan and one Republican supported it.
But it's a tougher fight for Democrats in the Senate, where it is much easier for the GOP minority to stifle the will of the Democratic majority.