(CNN) - As Harry Reid deals with the fallout from controversial comments, a new poll suggests the Senate majority leader faces an increasing difficult re-election this November.
Only one-third of Nevada voters have a favorable opinion of Reid, according to the survey by Mason-Dixon Polling and Research for the Last Vegas Review-Journal. The poll, released this weekend, indicates that a majority of voters in the state, 52 percent, hold an unfavorable opinion of their four-term senator. The 33 percent who see Reid in a positive light is down 5 points from November, with the unfavorable rating edging up 3 points.
The poll was conducted January 5-7, before news of Reid’s comments about then-presidential candidate Barack Obama's race sparked a controversy.
According to the survey, Reid trails three of his possible GOP challengers in hypothetical general election match-ups. The poll indicates Reid trails former Nevada GOP Chairwoman Sue Lowden by 10 points and businessman Danny Tarkanian by 8 points. Tarkanian is the son of former longtime University of Nevada-Las Vegas basketball coach Jerry Tarkanian. Reid also trails Sharron Angle by 5 points. Tarkanian and Lowden are deadlocked the primary battle among GOP voters.
One issue that may be hurting Reid is health care reform. The Senate majority leader is playing a large role in pushing the bill through his chamber, but only 35 percent of Nevada voters questioned support the legislation, with 54 percent opposed.
Reid has taken issue with polls from the Las Vegas-Review-Journal in the past.
Following a similar survey in October, Reid downplayed the results.
"All my polling numbers are fine," said the Senate Democratic leader. "They are not from a newspaper in Nevada that you guys tend to focus on. All my polling numbers are fine. And I'm continuing to do the best I can for the people of this country and the people of Nevada."
The release of the poll comes as one of the national conservative tea party organizations goes up with a television commercial against Reid in Nevada. The Tea Party Express said they're spending more than $100,000 to air their ad on television in the state starting Monday.
"Our message for Harry Reid is that your arrogance, your condescension and your failures as a Senator have not gone unnoticed. Don't be surprised when you receive a 'pink slip' from the voters come November,” said Mark Williams, vice chair of the Tea Party Express.
While Reid's bid for re-election could be tough, he does have a few advantages.
“Sen. Reid’s campaign advisors have pledged to spend upwards of $25 million to help him win re-election,” said CNN Political Editor Mark Preston. “That is a lot of money in Nevada. And even though Reid made those comments about Obama, I think that the president will do whatever is necessary to help him win another term. After all, Reid has been one of Obama’s closest allies on the Capitol Hill.”
The Mason-Dixon Polling and Research/Las Vegas Review-Journal poll was conducted by telephone with 625 active voters in Nevada questioned. The survey's overall sampling error is plus or minus 4 percentage points.
Follow Paul Steinhauser on Twitter: @psteinhausercnn