"Jonas Brothers are here tonight," the president said at the annual White House Correspondents' dinner. Daughters "Sasha and Malia are huge fans. But boys, don't get any ideas. Two words: predator drones."
Obama said he was happy to address the crowd before Leno, who headlined the annual event.
"Glad to see the only person whose ratings fell more than mine last year. ... I'm also glad that I'm speaking first," he said.
"We've seen what happens when someone takes the time slot after Leno," the president added, referring to comedian Conan O'Brien leaving NBC after an unsuccessful stint hosting "The Tonight Show."
Members of the Obama administration, including Vice President Joe Biden and chief of staff Rahm Emanuel, were not safe from the zingers either.
Former rivals and volatile current issues were also part of the stand-up.
The president noted that Arizona Sen. John McCain did not identify himself as a maverick this year - a title he frequently touted when he was running for presidency against Obama.