(CNN) - Louisiana Democratic Rep. Charlie Melancon is out Friday with a biting new ad that attacks incumbent Republican Senator David Vitter's 'sins,' as well as his voting record on women's issues.
The 30-second ad, entitled 'The Worst,' features a woman's voice combined with images of Vitter and his wife leaving a July 2007 press conference where Vitter admitted to having an extramarital affair and contacting an escort service.
The narrator says, "We know how David Vitter handled his serious sin."
"And when Vitter's staffer violently abused his girlfriend, Sen. Vitter let him keep his job working on women's issues," the ad continues as a photo of a woman with chin stitches is shown.
The NRSC issued a response on Friday, calling the ad "another desperate attempt by Charlie Melancon to distract voters from his years in Washington carrying water for Nancy Pelosi and President Obama."
"Louisianians overwhelmingly reject the reckless policies Melancon and his party bosses are ramming down their throats from Washington, and that's why voters will reelect Senator Vitter this November," NRSC spokesman Chris Bond said in a statement.
Both Vitter and Melancon are leading their respective primary races. Louisiana will hold its primaries on August 28.
–CNN Political Coverage Manager Steve Brusk contributed to this report