(CNN) – CNN senior political analyst David Gergen said Tea Party favorite Christine O'Donnell's Delaware upset could spell trouble for the Republican Party.
O'Donnell knocked off former governor and nine-time U.S. Rep. Mike Castle in the GOP Senate primary on Tuesday.
"It's the clearest rebellion we've had all season. The biggest anti-establishment vote that's occurring against Republican candidates," Gergen said.
"One clear result out of Delaware is the chances of Republicans now gaining the Senate have gone down significantly. Delaware was an automatic pickup for Republicans before Mike Castle went down," he said.
National Republicans have already indicated they're not likely to rally around O'Donnell amid concerns that she has no chance of winning the seat – once held by Vice President Biden for 26 years – in November.
"For moderate Republicans who are thinking about a future in the GOP, when Mike Castle goes down ... when he goes down to a Tea Party candidate you've got a real insurgency going on in the party and it's leaving a lot of moderate Republicans tonight shaking their heads, not quite sure what the future of the party is," he said.
That's what the Republicans get for McConnel & Boehner voting no on everything. They are only interested about big corporations and not the people.
Every tea party victory takes votes away from the republicans.
The democrats should be rejoicing as they watch tea party and republcians split votes.
This is the result of McConnel and Boehner saying NO to everything.
It's not that we liberals are any more liberal than we've been in the past, it's the fact that the Republicans have gone so extremely to the right, that anything right of center is considered "liberal" by the new radical extremist Republicans. I love the fact that they are hastening their own departure into obscurity and irrelevance.
The future of the Republican Party is bright. The rebellion against its more moderate establishment is a reaction to the outlandish policies by which President Obama, as if to make a told-you-so childish prank cum joke, sought to "CHANGE" America into his own Impossible Dream of a communistic, peace-in-the-valley Utopia.
As soon as we are removed in time from our traumatic experience with Mr. Obama's lunacy, rational Americans will return to more centrist thinking in both major parties.
Moderate Republican is code word for liberal. We have had enough of that. Liberals all but ruined this country. I am not a big Tea Party person but I can't take a Republican that supported Cap and Trade. He is part of the problem not part of the solution.