(CNN) - Potential 2012 GOP presidential candidates are slowly wading into the uprising in Egypt, all concerned about the ripple effects throughout the world.
Former Minnesota Gov. Tim Pawlenty went the furthest, calling for Egyptian President Hosni Mubarak to step down.
"I think his time is going to come to an end. It should come to an end," Pawlenty said Monday according to The Des Moines Register. "But as that vacuum gets filled, we want to do all we can to make sure it gets filled by institutions and people and leaders that share our principles, and values of freedom and democracy and human rights."
The Republican former governor said the Egyptian political infrastructure isn't "well-prepared for change," partly because the United States "allowed this vacuum to materialize underneath Mubarak."
Speaking to the Knesset, Israel's legislature Monday, former Arkansas Gov. Mike Huckabee said the protests may have international consequences.
"The events of the past few days in Egypt have created a very tenuous situation, not just for Egypt, not just for the Middle East, but for the entire world, and the destabilization of that nation has the potential of cascading across the globe," Huckabee said, according to The Jerusalem Post.
As part of his trip, Huckabee met with Israeli Prime Minister Benjamin Netanyahu on Monday.
Anti-government demonstrations started Tuesday throughout Egypt demanding an end to Mubarak's 30-year rule. Egyptians are protesting high unemployment, government corruption and poverty in the country.
Former Pennsylvania Sen. Rick Santorum compared the situation to the 1979 revolution in Iran that resulted in the overthrow of Iran's monarchy.
"We abandoned (the shah) and what we got in exchange was form the people if you will, notionally, was a radical Islamist regime," Santorum said Friday in an interview on Fox Business Network. "That happening in Egypt would have a profound effect on the Middle East."
"Let's be clear what the stakes are for the United States. We have an authoritarian regime in power that has been our ally," former U.N. Ambassador John Bolton told Fox News. "We don't know at this point what the real alternatives are."