(CNN) - Remember all that talk over the past week that Department of Homeland Security Secretary Janet Napolitano was thinking of running next year for the open Senate seat in her home state of Arizona?
Well, you can forget about it. The former Democratic governor of Arizona's apparently not interested.
"Secretary Napolitano told senior Democratic Party leaders earlier this week that she will not seek Arizona's open U.S. Senate seat in 2012. She cares deeply about Arizona, but the Secretary intends to continue doing the job that the President asked her to do – protecting the American people from terrorism and other threats to our country," says DHS Spokesman Sean Smith, in a statement Friday. "She's focused on continuing to strengthen our counter-terrorism initiatives, border security, immigration enforcement, transportation and cyber security, and disaster preparedness."
GOP Sen. Jon Kyl, the second ranking Republican in the chamber, announced eight days about that he would not run for a fourth term next year. Monday Republican Rep. Jeff Flake launched his bid for Kyl's seat. Flake instantly won the endorsement of the Club for Growth, a fiscally conservative organization that endorses and contributes to Republican candidates. He also grabbed the support of House Budget Committee chairman Paul Ryan.
Earlier this week Rep. Trent Franks told CNN that he was "seriously considering" running for Kyl's seat. Former GOP Rep. John Shadegg was a considered another contender for the open seat, but he said on Friday that he would not run. Other possible Republican candidates include Maricopa County Sheriff Joe Arpaio and state Senate President Russell Pearce.
On the Democratic side, Rep. Gabrielle Giffords had been contemplating a run for Senate before she was shot last month, Democratic sources last week confirmed to CNN. One Democratic congressman told CNN he talked to Giffords about it before the shooting, and says she was "very interested in the possibility of running for the Senate."
–CNN Congressional Producer Deirdre Walsh contributed to this report
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