(CNN) - Republican National Committee Chairman Reince Priebus called for the resignation of Rep. Anthony Weiner Tuesday, becoming the first major official to urge on Weiner to leave office.
"Congressman Weiner's actions and deception are unacceptable and he should resign," Priebus said in a statement. "We do not need an investigation to know he lied and acted inappropriately, we need a resignation."
The Democratic New York congressman admitted Monday to carrying on inappropriate relationships with several women he met online, after saying he did not post a lewd picture on his Twitter account last week.
Democratic Leader Rep. Nancy Pelosi called for a Congressional ethics investigation shortly after Weiner's press conference at which he said he would not resign his Congressional seat.
Priebus said Pelosi and Democratic National Committee Chairman Rep. Debbie Wasserman Schultz either "believe members of Congress are held to a different set of standards or they believe these actions demand his resignation."
The National Republican Congressional Committee started their own campaign Tuesday, urging Democrats who received donations from Weiner to return the campaign money.
There was no direct response from the Democratic Congressional Campaign Committee but DCCC Chairman Rep. Steve Israel issued a statement in support of Pelosi's call Monday.
"Congressman Anthony Weiner engaged in a deep personal failure and inappropriate behavior that embarrassed himself, his family and the House," Israel said in a statement. "Ultimately, Anthony and his constituents will make a judgment about this failure."