(CNN) - Actor Zach Galifianakis may be known for his less-than family-friendly sense of humor, but billionaires David and Charles Koch demonstrated Tuesday they don't find him so funny.
The comedian is co-starring with Will Ferrell in the upcoming comedy, "The Campaign," which features a pair of wealthy donors called the "Motch brothers," played by Dan Aykroyd and John Lithgow.
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Galifianakis, whose uncle served as a U.S. congressman from North Carolina, told the New York Daily News on Monday that it was "pretty obvious" the Motch brothers, a pair of wealthy donors who attempt to manipulate political campaigns, were crafted after David and Charles Koch, best known as the "Koch brothers."
The Koch brothers are high-profile figures in the Republican Party who support conservative and libertarian causes. Backers of the group Americans for Prosperity, the pair of industrialists are expected to spend tens – if not hundreds – of millions on Republican causes this year.
In July, the Kochs hosted a fund-raiser for Mitt Romney in Southampton, which drew multiple protests from Occupy Wall Street crowds.
In the interview Monday, "The Hangover" star wasted no time expressing how he feels about the real-life industrialist titans.
"I disagree with everything they do. They are creepy and there is no way around that. It's not freedom what they are doing," Galifianakis said.
Apparently, the real Koch brothers weren't so amused. A spokesman for the industrialist titans released a statement, chiding the actor's comments.
"Last we checked, the movie is a comedy. Maybe more to the point is that it's laughable to take political guidance or moral instruction from a guy who makes obscene gestures with a monkey on a bus in Bangkok," said Philip Ellender, referring to a scene from the movie "The Hangover Part II."
Ellender continued: "We disagree with his uninformed characterization of Koch and our beliefs. His comments, which appear to be based on false attacks made by our political opponents, demonstrate a lack of understanding of our longstanding support of individual freedom, freedom of expression, and constitutional rights."
"The Campaign" is produced by Warner Bros., which, like CNN, is owned by Time Warner.
– CNN's Mark Preston and Ashley Killough contributed to this report.