(CNN) - If Hillary Clinton decides to run for president in 2016, some critics on Twitter already know what slogan she should use: "What difference does it make?"
In a heated moment of anger, the secretary of state asked the question as she fought back criticism before the Senate Foreign Affairs Committee on Wednesday during a hearing on last year's U.S. consulate attack in Libya.
Republican Sen. Ron Johnson grilled Clinton on the erroneous, initial talking points that claimed the attack stemmed from a spontaneous protest against an anti-Islam video, though the administration later defined it as a terrorist attack and said a protest never happened.
After beating back the repeated questions, Clinton erupted.
"With all due respect, the fact is we had four dead Americans," she said. "Was it because of a protest or was it because of guys out for a walk one night decided they'd go kill some Americans? What difference, at this point, does it make? It is our job to figure out what happened and do everything we can to prevent it from ever happening again, senator."
But the Twitter-sphere quickly seized on the outburst.
John Kluska (@NeVet1) January 23, 2013
Not only did the hashtag spread, but so did a graphic of Clinton's 2008 campaign sign juxtaposed with the phrase "What difference does it make?"
al vinton (@withthetroops) January 23, 2013
Conservative commentator Michelle Malkin jumped on the train, as well.
Michelle Malkin (@michellemalkin) January 23, 2013
Within hours the hashtag was "trending" on Twitter.
Conservative think tank The Heritage Foundation also tweeted the phrase, along with video of U.S. Ambassador to the U.N. Susan Rice, who became the face of the erroneous talking points after she used them on numerous Sunday morning talk shows last September.
Heritage Foundation (@Heritage) January 23, 2013
Others took to humor, as this Twitter user, who tweaked a famous statement made by her husband when he was called to testify before a grand jury about the Monica Lewinsky affair.
It depends on what your definition of "It" is. #WhatDifferenceDoesItMake—
SmokeEater (@SmokeEater1978) January 23, 2013
– CNN's Ashley Killough contributed to this report.