(CNN) - Liz Cheney, daughter of former Vice President Dick Cheney, will challenge three-term Republican Sen. Michael Enzi of Wyoming for his seat in next year's mid-term elections, she announced Tuesday in a web video.
"Today I am launching my candidacy for the United States Senate," she said.
Cheney dedicated part of her nearly six-minute long video to criticizing President Barack Obama, accusing him of announcing a war on Americans' freedoms of religion and speech.
Missing, however, was any personal attacks on her GOP opponent, Enzi.
In her announcement she said it was time for a "new generation of leaders to step up." She then made a call to action, saying, "every victorious movement in history has required the full participation of men and women of courage, conviction and principle...join me in this fight."
Cheney, who chairs a nonprofit on national security and education called Keep America Safe, has been rumored this year to be considering a U.S. Senate bid from Wyoming.
The National Republican Senatorial Committee, however, says it stands firmly behind Enzi, the GOP incumbent.
"Our mission is to re-elect our incumbents and build a Republican majority," NRSC Communications Director Brad Dayspring told CNN.
Cheney sparked some speculation of a potential Senate bid in March when she cautioned her party against moving too far to the middle as the GOP began major rebranding efforts following last year's presidential loss.
"It is time for Republicans to get over their loss in 2012. We are all that stands between this president's policies and a damaged and diminished America," she wrote. "It is time to get back in the fight."
"And I do mean fight," she continued in the Wall Street Journal op-ed. "Republicans are being counseled to move the party to the left, but in my experience, those who advocate more liberal policies for the GOP are wrongheaded or Democrats, or both."
Wyoming is a reliably red state, with a Republican governor, Republican senators and a Republican for its at large representative. Enzi easily won re-election in 2008 with 76% of the vote.
Former Republican presidential nominee Mitt Romney carried the state 69% of the vote in last year's election.
– CNN's Jake Tapper, Paul Steinhauser and Ashley Killough contributed to this report.
A cold chill went up my back. Those Cheney's will do that to you. She may have a chance........it's Wyoming afterall.
Not a chance. Save your money and time.
The last thing this country needs is another Cheney involved in national politics..........please don't do this to us again Wyoming.
Sure hope Rand Paul, Ted Cruz, and her daddy campaign for her!
Poisonous last name will be her undoing.
So Enzi is not brain dead enough, and the lower life form lyin' Lizard can bring the GOP to the brink of extinction.
An easy win for Cheney. More dyspepsia in the Swamp. Huzzah.
Cool, maybe she can start a war there............
No "Cheney" should ever run for office again.
I'm sure Ms. Cheney is a fine young lady and well-qualified to become a US Senator. But she's gonna get whooped anyway!
I think the mission of the GOP should be less about getting incumbents relected but making sure that the best candidate representing their views gets elected. This is where it seems backwards and that parties are working for the politicians rather than for the people (their constituents).
LOL... you just cant make this stuff up.... These Repugs need to move to the moon
Just when we thought it couldn't get any worse, here comes Darth Vader's clone.
The last thing we need is a cheeney in the senate.
More political Nepotism. Clearly the only people these jerks can trust (to screw the country) are their own children.
Hurray let's let every relative of a former politician run for office!! Nepotism at its finest.
We need more Clintons, Bush's and Cheney's to run things
I guess she needs the money.
glad to know that another Cheney is doing their patriotic duty
She wants the GOP to move further to the lunatic right as opposed to the reasonable middle. HA! They're smart to want to steer clear of her.
She speaks about opposing Obama every step of the way. Spoken in the ongoing spirit of GOP cooperation .... how sad. That from the daughter of a war criminal for Vice President
woohoo...yeah, move it MORE to the right. That is obviously the view of most americans. Mandatory church, no sex before marriage, gays should be sent to "reassignment camps", pick a war with every country you can to bolster the economy,...and of course, here comes Palin to campaign with her....oh goodie....more crap news for 18 months.
Which daughter is this – the lesbian or the fascist?
What a Bitch hope she looses, enough of the GOP
Great – Mr. Burns' daughter is running. Is her heart as black as pitch and will she condone war crimes? Based on her comments about the GOP still not being too far to the right I would say yes.
Hooray for anti-moderates.