Washington (CNN) - There appears "to be some growing awareness" that "Russian insurgents" were behind the downing of a Malaysia Airlines jetliner in Ukraine on Thursday, Hillary Clinton said.
"If there is evidence pointing in that direction, the equipment had to have come from Russia," the former secretary of state and possible 2016 Democratic presidential candidate said.
"There is a great deal of concern that not only was a civilian plane shot down but what this means about the continuing conflict in eastern Ukraine and the role that Russia is playing," she added.
Her comments came as part of a sweeping interview with Charlie Rose on PBS and Bloomberg.
Malaysia Airlines Flight 17 was carrying nearly 300 passengers and crew when it crashed in a rebel-controlled area of eastern Ukraine.
The disaster prompted swift accusations from Ukrainian officials that "terrorists" shot it down. U.S. intelligence has also concluded that the plane was shot down. But it hasn't pinpointed who was responsible.
Clinton has made tough talk against Russian President Vladimir Putin a staple of her public remarks on foreign policy.
She told Rose that if Russia is held culpable, Europe should look to toughen its own sanctions over its incursion into Ukraine this year and accelerate efforts to break away from its use of Russian energy.
"Europeans have to be the ones to take the lead on this," Clinton said. "It was a flight from Amsterdam to Kuala Lumpur over European territory. There should be outrage in European capitals."
Putin is blaming Ukraine's military campaign against the separatists for the disaster.