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The victory technically gives the Arizona senator more than the required number of delegates to claim the GOP presidential nomination.
The Democratic races in Rhode Island and Texas remain competitive.
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CNN's Dana Bash reports that if John McCain surpasses the 1,191-delegate mark this evening - the number required to claim the GOP nomination - President Bush may officially endorse his presidential bid as soon as tomorrow.
A second GOP source familiar with these plans tells CNN McCain will go to the White House for the endorsement.
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(CNN) - There were concerns that Republican voters would participate in large numbers in the Democratic primaries in Ohio and Texas Tuesday and cause mischief, following a call by Rush Limbaugh for listeners to vote for Hillary Clinton.
Early exit polling shows 10 percent of the voters in Ohio's Democratic Primary identified themselves as Republican, along with 22 percent who said they were independents. It was the same story in Texas: 10 percent of the voters in the Democratic primary identified themselves as Republican, along with 25 percent who said they were independents.
–CNN's Joe Van Kanel
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(CNN) - Education level remains one of the biggest dividing lines in the Democratic race, and is clearly playing a role in the Ohio primary tonight.
Among those who reported that they attended college, Obama bested Clinton by 7 points. But among those voters who did not go to college, Clinton holds the clear advantage over the Illinois senator, 62-37 percent.
Blue collar voters have long constituted the core of Clinton's base and - in Ohio at least - they are sticking with the New York senator.
–CNN Senior Political Analyst Bill Schneider
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