[cnn-photo-caption image= http://i2.cdn.turner.com/cnn/2008/images/10/16/art.obamaad.cnn.jpg caption="The Obama campaign is out with a new ad from Wednesday's debate."]
(CNN) - Barack Obama's campaign is wasting no time in targeting one of John McCain's comments during the third and final debate Wednesday night.
In a new 30-second spot set to air nationally, the Illinois senator's campaign highlights one of the McCain's most emphatic statements of the evening: "Senator Obama, I am not President Bush."
The line was among the strongest of the evening for the Arizona senator, who has long grappled with how to escape the president's shadow.
"True, but you did vote with bush 90 percent of the time." The ad's narrator says. "Tax cuts for big corporations and the wealthy, but almost nothing for the middle-class - same as Bush. Keep spending 10 billion a month in Iraq when our economy struggles? Same as Bush."
The ad also shows some of McCain's more memorable reactions from Wednesday's debates, when the Republican presidential nominee was seen rolling his eyes and sighing.